Stephanie of Hohenzollern-Sigmaringen had married the young King of Portugal, Pedro V in May 1858. Just over a year later, the young queen, known as Estafania in Portugal, died of diptheria in Lisbon. Pedro, although he was also twenty-two years old, made no attempt to remarry and himself died in 1861 of cholera. (By John Osborne)
Source Citation
"Death of the Queen of Portugal," New York Times, August 1, 1859, p. 3.