William C. Round was born on April 23, 1842 to Methodist minister George Hopkins Round and his wife Mary Louisa McCants Round in Newton County, Georgia where his father was serving. He grew up in Cokesburg, South Carolina. He entered Dickinson College in Carlisle, Pennsylvania as a member of the class of 1863 in the fall of 1860. There, he joined his brother George Fiske Round of the class of 1861. Like so many other young men of the time, he withdrew from Dickinson, returned home, and enlisted at Abbeville, South Carolina into Company B of the First (Orr's) Rifles in the service of the Confederate States Army in June 1861.
He served in the CSA until his death at the Battle of Gaine's Mill in Virginia on June 27, 1862. He is buried under the Confederate Monument in Hollywood Cemetery in Richmond, Virginia. He was twenty years old.