Doctors of the visiting Japanese Embassy observe an operation using ether in Philadelphia
The doctors with the large party of Japanese diplomats making the historic first visit to the United States were invited to observe an operation at a private house during their visit to Philadelphia. A medical professor from Jefferson College removed gall bladder stones using ether as anesthetic, a procedure none of the visitors had seen before. They later visited Jefferson College and the Pennsylvania Hospital. (By John Osborne)
Francis Vincent, Vincent's Semi-Annual United States Register.... 1st of January and 1st of July, 1860 (Philadelphia: Francis Vincent, 1860), 516.