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The Dupont Gunpowder factory near Wilmington, Delaware suffer a heavy explosion that kills four workers

Fire and Earthquake Disasters, iconic image
The explosion at the Dupont Powder Mills was powerful enough to shake homes in the city of Wilmington, Delaware.  Four men were reported killed in the accident, which damaged nearby homes of mill workers and the Dupont family and displaced machinery and shattered all the windows in an unrelated factory on the other side of Brandywine Creek.  (By John Osborne)  
Source Citation: 
"The Explosion at Dupont's Powder Mills," New York Times, November 24, 1861.