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In Pittsburgh, Pennsylvania, an exploding boiler flies through four brick walls and kills twelve people

Fire and Earthquake Disasters, iconic image
In the early afternoon, a boiler in a marble cutting factory in Pittsburgh, Pennsylvania exploded.  The main section of the twenty-two feet long boiler was torn from its mountings and driven out of the factory, through a nearby clothing store, killing the owner, and then into a beer hall, killing a patron, before coming to rest in the cemetery of a Presbyterian church.  In all twelve men were killed and several others were injured in the explosion.  (By John Osborne) 
Source Citation: 
"Another Appalling Calamity - Explosion of A Boiler," New York Times, September 25, 1860.