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In Detroit, Michigan, a fire destroys much of the main building at the Michigan Central Railroad Depot

Fire at the Michigan Central Railroad Depot, Detroit, Michigan, October 18, 1865, artist's impression, detail
A fire broke out in the Michigan Central railyards in Detroit as a train was being being loaded in the evening with a cargo including varnish and benzene.  The fire spread in a strong breeze from the western end of the massive train shed, until much of the building was afire and threatening neighboring structures.  Efforts to contain the blaze succeeded, though, despite the total loss of an estimated million dollars. No serious injuries were reported. (By John Osborne)  
Source Citation: 
Robert Budd Ross, George Byron Catlin, Landmarks of Wayne County and Detroit (Detroit, MI: The Evening News Association, 1898), 472.
"Burning of the Michigan Central Depot," Harper's Weekly Magazine, November 4, 1865, p. 692.